Assuming that you are using a V rated coil, in my experience most probe recommendations are a little on the high side. I would focus on maintaining a high Discrimination Sensitivity and not push the RX Gain all the way up. I think anywhere between 3 - 12 on the RX is a good range for multi frequency modes. Single frequency modes can be set a little higher. You really see a jump in depth in moderate to low mineralization strength soils when you can get your Discrimination Sensitivity up to between 90 and 95. Non-V rated coils will not give accurate probe results in Multi frequency modes or in 22.5kHz single frequency. The 2.5kHz and 7.5kHz will be accurate however. You can usually set the RX a little higher than recommended with a Non V coil in multi frequency modes. I use a 10x12 SEF coil (non-V rated) a lot. I have my RX at 8 with a Discrimination Sensitivity of 90-92. I can hit a copper penny at 9 inches easily (Correlate mode). The probe in this case recommended an RX of 5. Hope this helps out. You might see higher signal loss, but the way I see it you have more signal to loose, so your still getting good feed back from the coil. Listen to your threshold. Above all make sure it is stable and smooth.
Jack